Are DEA registrants legally allowed to destroy unused controlled substances on site?

For expired/unused controlled substances, the registrant will need to complete a disposal log (DEA Form 41 – instructions here) and maintain that record onsite for at least two years. A copy of the DEA Form 41 can be found here. The registrant would complete a new form for each new Secure A Drug container. Official destruction of the drug occurs when it is wasted into the Secure A Drug because Secure A Drug renders the medication non-retrievable.

Be sure to check with your state board of pharmacy for local or state requirements in addition to those laid out by the DEA.